作者: Michael Holick , Alpdogan Kantarci , Hatice Hasturk , Thomas E. Van Dyke
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摘要: The present invention provides improved systems and methods for the local delivery of H2 antagonists. inventive include topical administration an effective amount a antagonist encapsulated in liposomes. In certain embodiments, antagonist, example, Cimetidine, is into paucilamellar liposomes, such as NOVASOME® microvesicles. Also provided are pharmaceutical compositions comprising liposome-encapsulated may be used to treat any disease state or condition where antagonists beneficial.