Compositions and methods for nucleic acid delivery
作者： Steven A. Castleberry , Paula T. Hammond
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摘要: The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof. In some embodiments, a structure includes substrate; on the substrate, wherein adjacent layers of are associated with one another via or more non-covalent interactions, comprises first nucleic acid agent at loading density, further is characterized in that, when placed subject so that contacts cells, released profile by feature selected from group consisting 1) being burst-free release; 2) sustained 3) exhibiting vitro and/or vivo biological effectiveness.
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