Cell Membranes Resist Flow.

摘要: The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to tension gradients. It is widely assumed that membrane transmits local changes across the cell milliseconds, mediating long-range signaling. Here, we show propagation of occurs quickly cell-attached blebs but largely suppressed intact cells. failure propagate cells explained by fluid dynamical incorporates resistance from cytoskeleton-bound transmembrane proteins. Perturbations diffusively, with diffusion coefficient Dσ ∼0.024 μm2/s HeLa In primary endothelial cells, increases lead only activation mechanosensitive ion channels and vesicle fusion. Thus, not mediator intracellular signaling, variations mediate distinct processes sub-cellular domains.