Incremental detection of HIV infections by the HIV antigen/antibody combination assays : An australian experience

摘要: Detection of acute cases human immunodeficiency virus (HIV) infection by the direct detection HIV antigen or nucleic acid assays is well known with an estimated 5-9 days reduction in pre-seroconversion 'window period' specific antibodies. The aim this study was to observe impact following routine introduction a screening assay which simultaneously detects (type 1 & 2) and antibody on yield multiple sites servicing different patient populations varying range risk factors associated acquisition. During first year (2003-2004), total 27 HIV-1 were identified HIV-1/2 Ab/Ag combo test confirmed be detectable for only that may have gone undetected should been used. Specimens referred from higher case load centers more likely provided relevant clinical information consistent retroviral syndrome history however there numerous where no provided. This shows antigen/antibody increases identification low prevalence setting represent important tool enhanced surveillance incident opportunities prevention.