Aldehyde adducts generated during lipid peroxidation modification of proteins

摘要: AbstractVarious lines of evidence indicate that an important part in the pathogenesis atherosclerosis is modification plasma low-density lipoproteins (LDLs). A large number pro-inflammatory and pro-atherogenic properties have been ascribed to oxidatively modified LDLs their components. There considerable support role lipid peroxidation products, reactive aldehydes particular, originating from oxidized LDL as signaling molecules context atherosclerotic lesion. These generated during exhibit a facile reactivity with proteins, generating variety intra- intermolecular covalent adducts on apolipoprotein B-100 particle LDL. Characterization aldehyde protein therefore critical understanding nature However, majority oxidative not yet chemically characterized. I...