Temporal profile of thromboxane-prostacyclin imbalance in experimental spinal cord injury.

摘要: Thromboxane-prostacyclin imbalance may be an important determinant of platelet-vessel wall interactions that are vital in circulatory homeostasis. In experimental spinal cord injury, the vascular damage contributes substantially to process progressive secondary injury culminating post-traumatic myelopathy. this study, we found a time-dependent alteration thromboxane-prostacyclin balance injured with thromboxane dominance during first 2 h: time when maximal is reflected by extravasation 125I-labelled serum albumin. The reverted favor prostacyclin 18 h post-injury. This should considered planning therapeutic attempts prevent pharmacological modulation interaction.