Fatigue as a symptom or comorbidity of neurological diseases

摘要: Fatigue, best described as an overwhelming feeling of tiredness and exhaustion, occurs in the context various neurological diseases. The high prevalence fatigue either a symptom or comorbidity disease must be taken seriously, interferes with patients' activities daily living, has remarkable negative impact on quality life, is major reason for early retirement. tremendous consequences are consistent across diseases, uncertainty concerning its underlying pathophysiological mechanisms. Inconsistencies defining contribute to present situation, which represents one least-studied least- understood conditions. Tools assessing abound, but few can recommended clinical research use. To make matters worse, evidence-based pharmacological treatment options scarce. However, non-pharmacological approaches currently promising likely become increasing importance. In sum, challenging both health-care professionals patients. article aims provide comprehensive review literature disease, reveal complexity, well weaknesses concept itself.