The Dopamine D5 Receptor Is Involved in Working Memory.

摘要: Pharmacological studies indicate that dopamine D1-like receptors (D1 and D5) are critically involved in cognitive function. However, the lack of pharmacological ligands selective for either D1 or D5 has made it difficult to determine unique contributions family members. To circumvent these limitations, we used receptor homozygous (-/-) heterozygous (+/-) knockout mice, identify specific role this higher order functions. We identified a novel regulation spatial working memory temporal The mutant mice acquired discrete paired-trial variable-delay T-maze task at normal rates. both [Formula: see text] exhibited impaired performance compared littermates when burden on faculties was imposed. In object recognition task, significant deficits. No D5-dependent differences locomotor functions interest exploring objects were evident. Molecular biomarkers dopaminergic within prefrontal cortex (PFC) revealed gene-dose effect Akt phosphorylation Ser473 with increased levels mice. A trend toward reduced CaMKKbeta brain-specific band (64 kDa) also These findings highlight previously unidentified function associated molecular signatures PFC.