International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck.

作者: Chiara Copelli , Enrico Sesenna , Frank Palmer , Ian Ganly , Snehal Patel

DOI: 10.1002/HED.23710

关键词:

摘要: Background The purpose of this study was to characterize the incidence, pattern spread, and prognostic correlation nerve invasion in patients with adenoid cystic carcinoma (ACC). Methods Using 3 different pathological categories perineural invasion, intraneural inflammation, we investigated value a total 495 ACCs from 9 international patient cohorts median follow-up 90 months (range, 12–288 months). Results Of 239 (48%) 174 (73%) had 65 (27%) 37 (15%) inflammation. Multivariate Cox regression analysis identified tumor site (p = .008; hazard ratio [HR] 1.8; 95% confidence interval [CI] 0.07–3.7) < .001; HR 5.9; CI 0.8–12.3) as independent markers for both overall survival (OS) disease-specific (DSS), but not distant metastases. Conclusion Although has no impact on survival, is an predictor poor prognosis. Recognition may help optimize treatment head neck ACC. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1038–1045, 2015

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