The Aquaporin3 Promoter Polymorphism -1431 A/G is Associated with Acute Graft Rejection and Cytomegalovirus Infection in Kidney Recipients Due to Altered Immune Cell Migration.

摘要: Major complications after kidney transplantation are graft rejection and cytomegalovirus (CMV) infection, which related to T-cell function, depends on aquaporin 3 (AQP3) expression. The impact of the AQP3 A(−1431)G promoter polymorphism in transplant recipients was unelucidated we explored effect immune cell function its association with CMV infection 237 adult patients within 12 months transplantation. molecular functional characterized. Kaplan–Meier plots evaluated relationship between genotypes incidence rejection. A-allele associated enhanced migration expression T-cells. incidences were 45.4% for 27.1% G-allele carriers (p = 0.005) a strong risk factor (hazard ratio (HR): 1.95; 95% CI: 1.216 3.127; p 0.006). 21% 35% 0.013) an independent 0.023), doubled (HR: 1.9; 1.154 3.128; 0.012). Hence, confers more resistance against but susceptibility mediated by Thus, AQP3-genotype adapted management immunosuppression antiviral prophylaxis seems prudent.