Cognitive functions in depression and anxiety disorders : findings from a population-based study

摘要: This doctorial thesis examines cognitive functions in depression and anxiety disorders a population-based sample that includes mostly untreated persons. It is well established associated with impairments. However, spite of the fact most depressed persons are untreated, almost all available evidence this field based on in-and outpatient samples. Also, little attention has been paid to functioning disorders. The four empirical studies were data from PART study, an ongoing study mental health Stockholm, Sweden. specific objectives Study I examine whether there association between abilities including episodic memory, verbal ability, psychomotor speed (TMT-A), executive function (TMT-B) as potential deficits vary DSM-IV defined diagnoses. Similarly, II we aimed relationship same observed impairments varied diagnosis. In III, major objective was recovery by following up three years later. IV, finally, investigate premorbid markers focus low memory performance. accomplished prospective examination cohort depression-free after baseline examination, at which group these received Results indicated depressive disorder dysfunction. Depression-related tests tapping function. Further, found diagnosed Major Depressive Disorder Mixed Anxiety showed significant functioning, whereas Dysthymia impaired Minor not be pattern results comparable observations I. We anxiety-related remained even controlling for comorbid depression. Specifically, Panic Syndrome (PD), Social Phobia (SP), Obsessive Compulsive (OCD) dysfunction, Specific not. addition, dysfunction then specifically affected PD OCD. non-significant alcohol abuse/dependence, suggesting excessive use may explain parts findings. III demonstrated recovered suffered continuous IV suggested performance, measured sum free cued recall, risk factor developing later independently demographic, clinical socioeconomic factors. Taken together, findings extend picture sampled population. present suggest persist beyond performance already before overall conclusion can drawn particular, but also anxiety, serious conditions affect indicating brain This, turn, have large negative impact, only working social lives society whole.