HIV-1 infection and cognitive impairment in the cART era: a review.

摘要: With the introduction of combination antiretroviral therapy AIDS dementia complex or HIV-associated dementia, as it was termed later, largely disappeared in clinical practice. However, past few years, patients, long-term infected and treated, including those with systemically well controlled infection, started to complain about milder memory problems slowness, difficulties concentration, planning, multitasking. Neuropsychological studies have confirmed that cognitive impairment occurs a substantial (15-50%) proportion patients. Among HIV-1-infected patients is one most feared complications HIV-1 infection. In addition, neurocognitive may affect adherence treatment ultimately result increased morbidity for systemic disease. So what be going on CNS after so many years apparently infection an urgent important challenge field HIV medicine. this review we summarize key currently available data. We describe neurological neuropsychological findings, preferred diagnostic approach new imaging techniques cerebrospinal fluid analysis. try integrate data pathogenesis finally discuss possible therapeutic interventions.