Noninvasive electromagnetic source imaging of spatiotemporally distributed epileptogenic brain sources

摘要: Brain networks are spatiotemporal phenomena that dynamically vary over time. Functional imaging approaches strive to noninvasively estimate these underlying processes. Here, we propose a novel source approach uses high-density EEG recordings map brain networks. This objectively addresses the long-standing limitations of conventional techniques, namely, difficulty in estimating spatial extent, as well temporal evolution sources. We validate our by directly comparing results with intracranial (iEEG) findings and surgical resection outcomes cohort 36 patients focal epilepsy. To this end, analyzed total 1,027 spikes 86 seizures. demonstrate capability both location extent from noninvasive electrophysiological measurements, specifically for ictal interictal Our is powerful tool investigating large-scale dynamic