XMRV: A New Virus in Prostate Cancer?

摘要: Several recent articles have reported the presence of a gammaretrovirus, termed "XMRV" (xenotropic murine leukemia virus-related virus) in prostate cancers (PCa). If confirmed, this could enormous implications for detection, prevention, and treatment PCa. However, other report failure to detect XMRV We tested nearly 800 PCa samples, using combination real-time PCR immunohistochemistry (IHC). The reactions were simultaneously monitored amplification single-copy human gene, confirm quality sample DNA its suitability PCR. Controls showed that assay single infected cell, even 10,000-fold excess uninfected cells. IHC used 2 rabbit polyclonal antisera, each prepared against purified virus (MLV) protein. Both antisera always stained XMRV-infected or -transfected cells, but never control No evidence was obtained these experiments. discuss possible explanations discrepancies results from different laboratories. It is not actually circulating population; if it is, data do seem support causal role