IGF Receptors in the Adult Brain

摘要: IGF-I action in the brain is not limited to its growth-promoting effects during fetal and neonatal development. Significant of adult have been demonstrated various contexts. The potent neuroprotective IGF was discovered vitro has confirmed vivo. proposed mechanisms neuroprotection depend on age, very interesting implications signaling neurodegeneration, notably amyotrophic lateral sclerosis Alzheimer's disease, observed. rescue neurons following administration extensively studied rodent models which a cerebrovascular accident caused by experimental ischemia/hypoxia. Discrepancies arisen observed vivo, possibly reflecting different actions exogenous endogenous IGF-I. Further studies are needed elucidate intracellular neuronal death hypoxia/ischemia role this process. Growing evidence demonstrates selective glial cells. However, few can address specific roles astrocytes microglia mediated signaling. Endothelial cells also respond IGF-I, mediating through control edema CNS damage. Recent longevity aging suggest that decreased insulin/insulin-like increases life span survival. Similarly, caloric restriction reduces levels circulation brain, at same time increasing organism. Paradoxically, excess promotes survival