Otic Administration of Amphotericin B 0.25% in Sterile Water:

摘要: OBJECTIVE:To report otic administration of parenteral amphotericin B 0.25% in sterile water.CASE SUMMARY:A 44-year-old HIV+ man was diagnosed with otitis extema. The patient's past medical history remarkable for positive Coccidioides immitis serology more than five months, essential hypertension, and Barrett's esophagitis. Culture results from an ear swab revealed 4+ Aspergillus fumigatus 3+ Staphylococcus, coagulase negative. Antiinfective therapy the otitisextema included oral topical antibacterial antifungal medications. AmphotericinB water prepared by pharmacy administration. dispensed instructions to refrigerate assigned a one-week expiration date. prescription called instillation 1–2 drops each three times day. signs symptoms extema resolved during several weeks antiinfective therapy. Topical ...