Novel hydrophilic nanostructured microtexture on direct metal laser sintered Ti-6Al-4V surfaces enhances osteoblast response in vitro and osseointegration in a rabbit model.
作者： Sharon L. Hyzy , Alice Cheng , David J. Cohen , Gustavo Yatzkaier , Alexander J. Whitehead
DOI: 10.1002/JBM.A.35739
关键词:
摘要: The purpose of this study was to compare the biological effects in vivo hierarchical surface roughness on laser sintered titanium-aluminum-vanadium (Ti-6Al-4V) implants those conventionally machined osteoblast response vitro and osseointegration. Laser disks were fabricated have micro-/nano-roughness wettability. Control computer numerical control (CNC) milled then polished be smooth (CNC-M). (LST-M), grit blasted (LST-B), or acid etched (LST-BE). LST-BE manufactured by CNC milling (CNC-B) implanted femurs male New Zealand white rabbits. Most differentiation markers local factors enhanced rough LST-B surfaces comparison CNC-M LST-M for MG63 normal human cells. To determine if osteogenic vivo, we compared them implant used clinically. had a unique with combined higher wettability than conventional CNC-B implants. Histomorphometric analysis demonstrated significant improvement cortical bone-implant contact after 3 6 weeks. However, mechanical testing revealed no differences between pullout forces at time points. LST production improved osseointegration process vivo. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2086-2098, 2016.
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