Phosphoenolpyruvate-succinate-glyoxylate pathway in the filarial parasiteSetaria digitata

摘要: Setaria digitata, a filarial parasite of cattle possesses certain unique characteristics like cyanide insensitivity, and lack cytochromes. In the present study, we have shown that has an incomplete tricarboxylic acid cycle with absence activities isocitrate dehydrogenase, α-ketoglutarate dehydrogenase succinyl-CoA synthase. However showed existence glyoxylate phosphoenolpyruvate-succinate pathway. The widely used antifilarial drug diethylcarbamazine caused general inhibition all enzymes pathway except fumarase lyase. results may pave way for new targets chemotherapy in control parasites.