Nitric Oxide and Cell Metabolism Dysfunction in the Metabolic Syndrome

摘要: Metabolic syndrome is a multifactorial, chronic disorder that has reached epidemic proportions in most industrialized countries and threatening to become global epidemic. defined by visceral fat accumulation, accompanied insulin resistance or type 2 diabetes mellitus, hypertension, hypertriglyceridemia, high uremic acid levels, low density lipoprotein (HDL) cholesterol. It now considered major cardiovascular risk factor large percentage of population worldwide. particularly challenging clinical condition treat because its complex molecular basis. Impaired cell metabolism been suggested as putative pathophysiological process leading the different features syndrome. In particular, defective oxidative seems be involved gain development skeletal muscle. This suggests mitochondrial function may impaired Syndrome. Recently, we have reported biogenesis are increased nitric oxide various types tissues. Interestingly, increasing evidence gaseous messenger might cellular metabolic sensor. implies production linked dysfunction. Here summarize our view on this issue propose novel hypothesis for Syndrome with therapeutic implications.