CD22 Is Required for Protection against West Nile Virus Infection
作者： D. Y. Ma , M. S. Suthar , S. Kasahara , M. Gale , E. A. Clark
DOI: 10.1128/JVI.02368-12
关键词:
摘要: West Nile virus (WNV) is a RNA of the family Flaviviridae and leading cause mosquito-borne encephalitis in United States. Humoral immunity essential for protection against WNV infection; however, requirements initiating effective antibody responses infection are still unclear. CD22 (Siglec-2) expressed on B cells regulates cell receptor signaling, survival, proliferation, production. In this study, we investigated how contributes to found that knockout (Cd22(-/-)) mice were highly susceptible had increased viral loads serum central nervous system (CNS) compared wild-type (WT) mice. This was not due defect humoral immunity, as Cd22(-/-) normal WNV-specific responses. However, decreased CD8(+) T those WT These defects simply reduced cytotoxic activity or death but, rather, associated with lymphocyte migration into draining lymph nodes (dLNs) infected production chemokine CCL3 dLNs after infection, suggesting affects chemotaxis via controlling restricted but also subset splenic DCIR2(+) dendritic rapidly expand early infection. Thus, plays an role by governing
sci-hub.se 参考文章(62)
J Tuscano, P Engel, TF Tedder, JH Kehrl, Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation Blood. ,vol. 87, pp. 4723- 4730 ,(1996) , 10.1182/BLOOD.V87.11.4723.BLOODJOURNAL87114723
Flora Castellino, Alex Y. Huang, Grégoire Altan-Bonnet, Sabine Stoll, Clemens Scheinecker, Ronald N. Germain, Chemokines enhance immunity by guiding naive CD8 + T cells to sites of CD4 + T cell–dendritic cell interaction Nature. ,vol. 440, pp. 890- 895 ,(2006) , 10.1038/NATURE04651
Sanjiv A. Luther, Jason G. Cyster, Chemokines as regulators of T cell differentiation Nature Immunology. ,vol. 2, pp. 102- 107 ,(2001) , 10.1038/84205
K. Grabstein, E. A. Clark, L. Santos-Argumedo, R. M. Torres, R. M. E. Parkhouse, P. A. Kirkham, Che-Leung Law, Identification and characterization of the murine homologue of CD22, a B lymphocyte-restricted adhesion molecule. Journal of Immunology. ,vol. 149, pp. 2641- 2649 ,(1992)
E A Clark, G Moldenhauer, B Dörken, A Pezzutto, Amplification of human B cell activation by a monoclonal antibody to the B cell-specific antigen CD22, Bp 130/140. Journal of Immunology. ,vol. 138, pp. 98- 103 ,(1987)
E. A. Clark, K. A. Chandran, A. Aruffo, R. T. Doty, Che-Leung Law, Ig domains 1 and 2 of murine CD22 constitute the ligand-binding domain and bind multiple sialylated ligands expressed on B and T cells. Journal of Immunology. ,vol. 155, pp. 3368- 3376 ,(1995)
Anne-Claire Bréhin, Juliette Mouriès, Marie-Pascale Frenkiel, Gilles Dadaglio, Philippe Desprès, Monique Lafon, Thérèse Couderc, Dynamics of immune cell recruitment during West Nile encephalitis and identification of a new CD19+B220-BST-2+ leukocyte population. Journal of Immunology. ,vol. 180, pp. 6760- 6767 ,(2008) , 10.4049/JIMMUNOL.180.10.6760
James D. Brien, Jennifer L. Uhrlaub, Janko Nikolich-Žugich, West Nile virus-specific CD4 T cells exhibit direct antiviral cytokine secretion and cytotoxicity and are sufficient for antiviral protection. Journal of Immunology. ,vol. 181, pp. 8568- 8575 ,(2008) , 10.4049/JIMMUNOL.181.12.8568
Lorna Santos, Kevin E. Draves, Mark Boton, Prabhjit K. Grewal, Jamey D. Marth, Edward A. Clark, Dendritic cell-dependent inhibition of B cell proliferation requires CD22. Journal of Immunology. ,vol. 180, pp. 4561- 4569 ,(2008) , 10.4049/JIMMUNOL.180.7.4561
Chang H. Kim, Hal E. Broxmeyer, Chemokines: signal lamps for trafficking of T and B cells for development and effector function. Journal of Leukocyte Biology. ,vol. 65, pp. 6- 15 ,(1999) , 10.1002/JLB.65.1.6