Catabolism of very low density lipoproteins in experimental nephrosis.

摘要: The effects of experimental nephrosis in rats, produced by puromycin aminonucleoside, include an elevation plasma levels all lipoprotein density classes and the appearance high (HDL) rich apoprotein (apo) A-I deficient apo A-IV E. hyperlipoproteinemia is associated with increase hepatic synthesis lipoproteins. possible role decreased very low (VLDL were obtained from nonfasting animals ultracentrifugation at d 1.006 included chylomicrons) catabolism its relationship to apolipoprotein composition nephrotic lipoproteins (1.063 less than 1.210, or 1.072 1.210 [HDL]) was explored. When 125I-VLDL injected, faster clearance lower molecular weight B (apo BL) compared that higher BH which seen normal rats not observed rats. Less labeled phospholipid, C, E transferred VLDL classes. Heparin-releasable lipase activities 50% pair-fed controls. Perfusion livers medium contained heparin released activity injected intravenously, significant decreases triglycerides increases free fatty acids both groups animals. In 86% fractions, as 16% Heparin treatment did restore BL but it increased amount HDL. vitro addition partially pure whole serum significantly content We conclude abnormal HDL result altered entry apolipoproteins triglyceride-rich lipoproteins, probably because lipolysis.