Appearance of untreated bone metastases from breast cancer on FDG PET/CT: importance of histologic subtype

摘要: To determine if the histology of a breast malignancy influences appearance untreated osseous metastases on FDG PET/CT. This retrospective study was performed under IRB waiver. Our Hospital Information System screened for cancer patients who presented with metastases, underwent PET/CT prior to systemic therapy or radiotherapy from 2009 2012. Patients invasive ductal carcinoma (IDC), lobular (ILC), mixed ductal/lobular (MDL) were included. history other malignancies excluded. evaluated, blinded histology, classify per-patient basis as sclerotic, lytic, lytic/sclerotic, occult CT, and record SUVmax PET. Following screening, 95 met inclusion criteria (74 IDC, 13 ILC, 8 MDL) ILC more commonly sclerotic demonstrated lower than IDC metastases. In all MDL at least one FDG-avid. For lytic FDG-avid metastasis; however, in only three seven apparent The histologic subtype affects particular, non-FDG-avid common IDC. Breast should be considered when interpreting lesions PET/CT, which may suspicious (rather benign lesions) ILC.