Emetine inhibits migration and invasion of human non-small-cell lung cancer cells via regulation of ERK and p38 signaling pathways.
作者： Ji Hyun Kim , Eun Byul Cho , Jongsung Lee , Okkeun Jung , Byung Jun Ryu
DOI: 10.1016/J.CBI.2015.08.014
关键词:
摘要: Emetine is a natural compound originated from ipecac roots. It was commonly used as anti-protozoal and vomiting agent. The apoptosis-inducing effect of emetine makes it considered potential anti-cancer agent for various human cancers. Here in this study, we report that inhibits migration invasion non-small-cell lung cancer (NSCLC) cells. Modulation three major mitogen-activated protein kinases (MAPKs), ERK, p38 JNK, well known to be involved regulation matrix metalloproteinases (MMPs), which are essential tissue remodeling extracellular (ECM) degradation, cells spread out the origin tumorigenesis. regulates two MAPKs, ERK. Differential inhibition/stimulation ERK induced differential suppressions β-catenin c-myc transcription factors. This leads selective down-regulation MMP-2 MMP-9, gelatinases can degrade ECM components, RECK, negative regulator MMP-9.
core.ac.uk 
sci-hub.se 参考文章(24)
Jukka Westermarck, Veli‐Matti Kähäri, Regulation of matrix metalloproteinase expression in tumor invasion The FASEB Journal. ,vol. 13, pp. 781- 792 ,(1999) , 10.1096/FASEBJ.13.8.781
Frank T. Kolligs, Guido Bommer, Burkhard Göke, Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. Digestion. ,vol. 66, pp. 131- 144 ,(2002) , 10.1159/000066755
Anita Wolfer, Sridhar Ramaswamy, MYC and Metastasis Cancer Research. ,vol. 71, pp. 2034- 2037 ,(2011) , 10.1158/0008-5472.CAN-10-3776
Elena I. Deryugina, James P. Quigley, Matrix metalloproteinases and tumor metastasis Cancer and Metastasis Reviews. ,vol. 25, pp. 9- 34 ,(2006) , 10.1007/S10555-006-7886-9
Mark Bond, Alex J Chase, Andrew H Baker, Andrew C Newby, Inhibition of transcription factor NF-κB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells Cardiovascular Research. ,vol. 50, pp. 556- 565 ,(2001) , 10.1016/S0008-6363(01)00220-6
Young Min Kim, Min Jeong Ku, Young-Jin Son, Jung-Mi Yun, Seong Hwan Kim, Sang Yeol Lee, Anti-metastatic effect of cantharidin in A549 human lung cancer cells Archives of Pharmacal Research. ,vol. 36, pp. 479- 484 ,(2013) , 10.1007/S12272-013-0044-3
Ilias Muhammad, D. Chuck Dunbar, Shabana I. Khan, Babu L. Tekwani, Erdal Bedir, Satoshi Takamatsu, Daneel Ferreira, Larry A. Walker, Antiparasitic alkaloids from Psychotria klugii. Journal of Natural Products. ,vol. 66, pp. 962- 967 ,(2003) , 10.1021/NP030086K
E.W. Street, CYCLOPHOSPHAMIDE PLUS EMETINE IN LUNG CANCER The Lancet. ,vol. 300, pp. 381- 382 ,(1972) , 10.1016/S0140-6736(72)91771-0
Chi V. Dang, MYC on the Path to Cancer Cell. ,vol. 149, pp. 22- 35 ,(2012) , 10.1016/J.CELL.2012.03.003
Byung Jun Ryu, Hyuk Lee, Seong-Ho Kim, Jung-Nyoung Heo, Sik-Won Choi, Jeong-Tae Yeon, Jeongmin Lee, Jongsung Lee, Jae Youl Cho, Seong Hwan Kim, Sang Yeol Lee, PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings Molecular and Cellular Biochemistry. ,vol. 389, pp. 69- 77 ,(2014) , 10.1007/S11010-013-1928-8