Multicenter Study of General Anesthesia III. Predictors of Severe Perioperative Adverse Outcomes

摘要: Little information is available about the incidence of severe adverse outcomes, and even less identification quantification independent predictors perioperative outcomes. The purpose this study was to identify quantitate outcomes in a prospective randomized clinical trial general anesthesia 17,201 patients. Twenty-nine prognostic variables for 15 847 patients were tested by multiple stepwise logistic regressions from which 20 significant (P than 0.05) identified. A history cardiac failure or myocardial infarction equal 1 yr; ASA physical status 3 4; age greater 50 cardiovascular, thoracic, abdominal neurologic surgery; anesthetics "any outcome, including death." There 17 10 cardiovascular 608 patients, ventricular arrhythmia, hypertension, failure, ischemia, yr yr, smoking; status; age; abdominal, eyes-ears-nose-throat/endocrine, neurologic, musculoskeletal, gynecologic anesthetics. 9 4 respiratory 163 chronic obstructive pulmonary disease; obesity; male gender; Colinearity between related (such as disease status) assessed using progressively segregated groups eight regressions. We conclude that comprehensive regression 29 reported here provides valid estimate risks associated with anesthesia.