DCLK1 Monoclonal Antibody-Based CAR-T Cells as a Novel Treatment Strategy against Human Colorectal Cancers.
作者： Sripathi M. Sureban , Robert Berahovich , Hua Zhou , Shirley Xu , Lijun Wu
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摘要: … models of colorectal cancer (CRC). Here, we describe a novel CAR-T targeting DCLK1 (CBT-… mice were treated with CBT-511 or mock CAR-T cells. Adherent CRC cells express surface …
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Gideon Gross, Zelig Eshhar, Therapeutic Potential of T Cell Chimeric Antigen Receptors (CARs) in Cancer Treatment: Counteracting Off-Tumor Toxicities for Safe CAR T Cell Therapy Annual Review of Pharmacology and Toxicology. ,vol. 56, pp. 59- 83 ,(2016) , 10.1146/ANNUREV-PHARMTOX-010814-124844
Fan Fan, Shaija Samuel, Kurt W. Evans, Jia Lu, Ling Xia, Yunfei Zhou, Eric Sceusi, Federico Tozzi, Xiang‐Cang Ye, Sendurai A. Mani, Lee M. Ellis, Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells. Cancer Medicine. ,vol. 1, pp. 5- 16 ,(2012) , 10.1002/CAM4.4
Samy Lamouille, Jian Xu, Rik Derynck, Molecular mechanisms of epithelial–mesenchymal transition Nature Reviews Molecular Cell Biology. ,vol. 15, pp. 178- 196 ,(2014) , 10.1038/NRM3758
Dejuan Kong, Sanjeev Banerjee, Aamir Ahmad, Asfar Sohail Azmi, Shadan Ali, James L. Abbruzzese, Gary E. Gallick, Fazlul H. Sarkar, Zhiwei Wang, Yiwei Li, Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway Cancer Research. ,vol. 69, pp. 2400- 2407 ,(2009) , 10.1158/0008-5472.CAN-08-4312
Sripathi M. Sureban, Randal May, Satish Ramalingam, Dharmalingam Subramaniam, Gopalan Natarajan, Shrikant Anant, Courtney W. Houchen, Selective Blockade of DCAMKL-1 Results in Tumor Growth Arrest by a Let-7a MicroRNA-Dependent Mechanism Gastroenterology. ,vol. 137, pp. 649- 659 ,(2009) , 10.1053/J.GASTRO.2009.05.004
Michael F Clarke, John E Dick, Peter B Dirks, Connie J Eaves, Catriona HM Jamieson, D Leanne Jones, Jane Visvader, Irving L Weissman, Geoffrey M Wahl, None, Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Research. ,vol. 66, pp. 9339- 9344 ,(2006) , 10.1158/0008-5472.CAN-06-3126
Thomas Brabletz, EMT and MET in Metastasis: Where Are the Cancer Stem Cells? Cancer Cell. ,vol. 22, pp. 699- 701 ,(2012) , 10.1016/J.CCR.2012.11.009
C. Benedikt Westphalen, Samuel Asfaha, Yoku Hayakawa, Yoshihiro Takemoto, Dana J. Lukin, Andreas H. Nuber, Anna Brandtner, Wanda Setlik, Helen Remotti, Ashlesha Muley, Xiaowei Chen, Randal May, Courtney W. Houchen, James G. Fox, Michael D. Gershon, Michael Quante, Timothy C. Wang, Long-lived intestinal tuft cells serve as colon cancer–initiating cells Journal of Clinical Investigation. ,vol. 124, pp. 1283- 1295 ,(2014) , 10.1172/JCI73434
Gregory L. Beatty, Whitney L. Gladney, Immune Escape Mechanisms as a Guide for Cancer Immunotherapy Clinical Cancer Research. ,vol. 21, pp. 687- 692 ,(2015) , 10.1158/1078-0432.CCR-14-1860
Sripathi M Sureban, Randal May, Nathaniel Weygant, Dongfeng Qu, Parthasarathy Chandrakesan, Eddie Bannerman-Menson, Naushad Ali, Panayotis Pantazis, Christoph B Westphalen, Timothy C Wang, Courtney W Houchen, None, XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism Cancer Letters. ,vol. 351, pp. 151- 161 ,(2014) , 10.1016/J.CANLET.2014.05.011