Chapter 7 Membrane Properties and the Activation of Protein Kinase C and Phospholipase A2

摘要: Publisher Summary The structure of lipid bilayer membranes attracts increasing interest because the realization that activities many key intracellular enzymes, especially those involved in metabolism and transmembrane signal transduction, may be modulated by structure/composition cell membranes. defects structure, variously described as packing “irregularities,” “stress” or “strain,” “increased fluctuations,” have long been implicated important factors determining protein-lipid interactions activity some intrinsic membrane proteins membrane-active notably phospholipases. Among most studied these enzymes are two considered this chapter a paradigm effects on biological functions cell: PKC PLA2. While number biologically active lipids affect primary focus here is class ubiquitous well-studied second messenger molecules, DAGs, both resulting modulation different species DAGs PLAz activities.