Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution.
作者： Klára Valkó
DOI: 10.1016/J.CHROMA.2003.10.084
关键词:
摘要: Octanol-water partition coefficients are the most widely used measure of lipophilicity in modelling biological partition/distribution. It has long been recognised that retention a compound reversed-phase liquid chromatography is governed by its lipophilicity/hydrophobicity, and thus shows correlation with an octanol-water coefficient. A great number publications have reported efforts made to adjust HPLC conditions surrogate coefficients. However, there no general consensus this field. provides platform various types can provide relevant information about compounds' property. In way be more valuable than just for partition. Chromatography using biomimetic stationary phases may better insight partition/distribution processes. The research field still ongoing large variety suggested. This review will outline approaches overcoming difficulties standardisation describe different theoretical comparison data obtained under conditions, along relation these results
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sci-hub.se 参考文章(62)
Thomas Braumann, Gert Weber, L.Horst Grimme, Quantitative structure—activity relationships for herbicides Journal of Chromatography A. ,vol. 261, pp. 329- 343 ,(1983) , 10.1016/S0021-9673(01)87961-9
Han van de Waterbeemd, Dennis A. Smith, Barry C. Jones, Lipophilicity in PK design: methyl, ethyl, futile. Journal of Computer-aided Molecular Design. ,vol. 15, pp. 273- 286 ,(2001) , 10.1023/A:1008192010023
John G. Dorsey, Morteza G. Khaledi, Hydrophobicity estimations by reversed-phase liquid chromatography : implications for biological partitioning processes Journal of Chromatography A. ,vol. 656, pp. 485- 499 ,(1993) , 10.1016/0021-9673(93)80815-P
Gonzalo Colmenarejo, Ana Alvarez-Pedraglio, José-Luis Lavandera, Cheminformatic models to predict binding affinities to human serum albumin. Journal of Medicinal Chemistry. ,vol. 44, pp. 4370- 4378 ,(2001) , 10.1021/JM010960B
John M. McCall, Liquid-lipquid partition coefficients by high-pressure liquid chromatography. Journal of Medicinal Chemistry. ,vol. 18, pp. 549- 552 ,(1975) , 10.1021/JM00240A003
M. Harnisch, H.J. Möckel, G. Schulze, Relationship between log Pow, shake-flask values and capacity factors derived from reversed-phase high-performance liquid chromatography for n-alkylbenzenes and some oecd reference substances Journal of Chromatography A. ,vol. 282, pp. 315- 332 ,(1983) , 10.1016/S0021-9673(00)91610-8
Klára Valkó, Chris Bevan, Derek Reynolds, Chromatographic Hydrophobicity Index by Fast-Gradient RP-HPLC: A High-Throughput Alternative to log P/log D. Analytical Chemistry. ,vol. 69, pp. 2022- 2029 ,(1997) , 10.1021/AC961242D
Csaba. Horvath, Wayne. Melander, Imre. Molnar, Liquid chromatography of ionogenic substances with nonpolar stationary phases Analytical Chemistry. ,vol. 49, pp. 142- 154 ,(1977) , 10.1021/AC50009A044
Michael H Abraham, Harpreet S Chadha, Ruben AE Leitao, Robert C Mitchell, William J Lambert, Roman Kaliszan, Antoni Nasal, Piotr Haber, None, Determination of solute lipophilicity, as log P(octanol) and log P(alkane) using poly(styrene–divinylbenzene) and immobilised artificial membrane stationary phases in reversed-phase high-performance liquid chromatography Journal of Chromatography A. ,vol. 766, pp. 35- 47 ,(1997) , 10.1016/S0021-9673(96)00977-6
Ann M. Talbert, George E. Tranter, Elaine Holmes, Peter L. Francis, Determination of drug-plasma protein binding kinetics and equilibria by chromatographic profiling: exemplification of the method using L-tryptophan and albumin. Analytical Chemistry. ,vol. 74, pp. 446- 452 ,(2002) , 10.1021/AC010643C