n-3 fatty acids in psoriasis.

摘要: Increased concentrations of free arachidonic acid (AA) and its proinflammatory metabolites have been observed in psoriatic lesions. Replacement by alternative precursor polyunsaturated fatty acids (PUFA), especially eicosapentaenoic (EPA), which can be metabolized via the same enzymatic pathways as AA, might a therapeutic option psoriasis. However results studies evaluating benefit dietary fish oil conflicting not clearly dose-dependent. To overcome slow kinetics limited availability oral supplementation, we performed three to assess efficacy safety an intravenously administered derived lipid emulsion on different forms Patients received daily infusions either n-3 acid-based (Omegaven®) or conventional n-6 (Lipoven®) time dose regimens. In addition overall assessment clinical course psoriasis, EPA- AA-derived neutrophil 5-lipoxygenase (LO)-products, thromboxane (TX) B 2 /B 3 , PAF plasma were investigated. Treatment with resulted considerably higher response rate than infusion lipids. A more 10-fold increase EPA-derived 5-LO product formation was noted group, accompanied rapid plasma-free EPA within first days. conclusion, intravenous n-3-fatty administration causes reduction may related changes inflammatory eicosanoid generation. The rapidity lipids exceeds orders magnitude hitherto reported improvement lesions upon use supplementation.