Immunological Abnormalities in the Antiphospholipid Syndrome

摘要: Publisher Summary This chapter focuses on various immunological abnormalities in the antiphospholipid syndrome (APS). APS is known to belong family of autoimmune diseases, which are characterized by antibodies directed autoantigens and therefore, called autoantibodies. likely be occurring when tolerance endogenous β2GPI lost. As most including organ specific ones, responses can against several autoantigens. Besides β2GPI, other phospholipids binding proteins have been investigated as possible targets for aPL, include autoantibodies prothrombin (PT), protein C S (PC PS), thrombomodulin (TM), Annexin V (AV), high molecular weight kininogen. A peculiar kind aPL zwitterionic phospholipid such phosphatidylcoline (PC) IgM isotype, belonging category natural autoantibodies, recorded patients with haemolytic anaemia (both idiopathic within SLE), therefore regarded a aspect APS. subset antinuclear nuclear lamins identified primary may justify, at least part, prevalence ANA reported disease. Antilamin Bl strongly associated both LLD or SLE. The anti-lamin B1 LA significantly lower risk thrombosis compared without antibodies.