Long-term exposure to diesel engine exhaust induced lung function decline in a cross sectional study
作者： Li Ping ZHANG , Xiao ZHANG , Hua Wei DUAN , Tao MENG , Yong NIU
DOI: 10.2486/INDHEALTH.2016-0031
关键词:
摘要: To clarify the effects of lung function following exposure to diesel engine exhaust (DEE), we recruited 137 testing workers exposed DEE and 127 non-DEE-exposed as study subjects. We performed tests measured cytokinesis-block micronucleus (CBMN) cytome index levels urinary polycyclic aromatic hydrocarbons (PAHs) metabolites. There was a significant decrease forced expiratory volume in 1 second (FEV1), ratio vital capacity (FEV1/ FVC), maximal mid flow curve (MMF), at 50% FVC (FEF50%), 75% (FEF75%) DEE-exposed than (all p<0.05). Among all subjects, decreases FEF75% were associated with increasing PAHs meta-bolites (p<0.05), there negative correlations between FEV1, FEV1/FVC, MMF, FEF50%, CBMN Our results show that long-term can induce decline which shows mainly obstructive changes influence small airways function. The decreased is internal dosage exposure, accompany index.
sci-hub.se 参考文章(38)
David A. Morgott, Factors and Trends Affecting the Identification of a Reliable Biomarker for Diesel Exhaust Exposure Critical Reviews in Environmental Science and Technology. ,vol. 44, pp. 1795- 1864 ,(2014) , 10.1080/10643389.2013.790748
Ulf Ulfvarson, Rolf Alexandersson, Monica Dahlqvist, Ulla Ekholm, Björn Bergström, Pulmonary function in workers exposed to diesel exhausts: the effect of control measures. American Journal of Industrial Medicine. ,vol. 19, pp. 283- 289 ,(1991) , 10.1002/AJIM.4700190303
Lamia Benbrahim-Tallaa, Robert A Baan, Yann Grosse, Béatrice Lauby-Secretan, Fatiha El Ghissassi, Véronique Bouvard, Neela Guha, Dana Loomis, Kurt Straif, Carcinogenicity of diesel-engine and gasoline-engine exhausts and some nitroarenes Lancet Oncology. ,vol. 13, pp. 663- 664 ,(2012) , 10.1016/S1470-2045(12)70280-2
Christos Hatzis, John J. Godleski, Beatriz González-Flecha, Jack M. Wolfson, Petros Koutrakis, Ambient Particulate Matter Exhibits Direct Inhibitory Effects on Oxidative Stress Enzymes Environmental Science & Technology. ,vol. 40, pp. 2805- 2811 ,(2006) , 10.1021/ES0518732
J E Hart, F Laden, E A Eisen, T J Smith, E Garshick, Chronic obstructive pulmonary disease mortality in railroad workers Occupational and Environmental Medicine. ,vol. 66, pp. 221- 226 ,(2008) , 10.1136/OEM.2008.040493
Thomas W. Hesterberg, Christopher M. Long, William B. Bunn, Sonja N. Sax, Charles A. Lapin, Peter A. Valberg, Non-cancer health effects of diesel exhaust: A critical assessment of recent human and animal toxicological literature Critical Reviews in Toxicology. ,vol. 39, pp. 195- 227 ,(2009) , 10.1080/10408440802220603
Ariane Leroyer, Fanny Jeandel, Anne Maitre, Mike Howsam, Dominique Deplanque, Muriel Mazzuca, Catherine Nisse, 1-Hydroxypyrene and 3-hydroxybenzo[a]pyrene as biomarkers of exposure to PAH in various environmental exposure situations Science of The Total Environment. ,vol. 408, pp. 1166- 1173 ,(2010) , 10.1016/J.SCITOTENV.2009.10.073
Jaime E. Hart, Ellen A. Eisen, Francine Laden, Occupational diesel exhaust exposure as a risk factor for chronic obstructive pulmonary disease. Current Opinion in Pulmonary Medicine. ,vol. 18, pp. 151- 154 ,(2012) , 10.1097/MCP.0B013E32834F0EAA
Xiao Zhang, Huawei Duan, Feng Gao, Yuanyuan Li, Chuanfeng Huang, Yong Niu, Weimin Gao, Shanfa Yu, Yuxin Zheng, Increased micronucleus, nucleoplasmic bridge, and nuclear bud frequencies in the peripheral blood lymphocytes of diesel engine exhaust-exposed workers. Toxicological Sciences. ,vol. 143, pp. 408- 417 ,(2015) , 10.1093/TOXSCI/KFU239
Gabriele Lotz, Sabine Plitzko, Erhardt Gierke, Ulrike Tittelbach, Norbert Kersten, W. Dietmar Schneider, Dose-response relationships between occupational exposure to potash, diesel exhaust and nitrogen oxides and lung function: cross-sectional and longitudinal study in two salt mines. International Archives of Occupational and Environmental Health. ,vol. 81, pp. 1003- 1019 ,(2008) , 10.1007/S00420-007-0294-9