Acetylcholinesterase and neuropathy target esterase activities in 11 cases of symptomatic flight crew members after fume events.

摘要: In modern aviation, so-called fume events such as exposure to an unknown mixture of chemicals introduced into the aircraft cabin with bleed air drawn off at engines may occur. Human result in (neuro)toxic symptoms described "aerotoxic syndrome." Currently, among other agents organophosphates (OP) are regarded a likely cause observed adverse effects. After 11 flight crew members (9 female/2 male; ages 23-58 yr) were admitted for medical examination within 5 d post exposure. Individual acetylcholinesterase (AChE) and neuropathy target esterase (NTE) activities determined. Anamnesis clinical findings confirmed prominent intoxication, including headache, cognitive difficulties, neurological disorders, others. Patient AChE ranged from 37 50 U/g hemoglobin (reference values: 26.7-50.9 hemoglobin). Ten individuals showed NTE ranging 3.14 6.3 nmol phenyl valerate/(min × mg protein) 3.01-24), one patient exhibiting low activity 1.4. Biochemical effect monitoring was applied encompass broad range AChE-inhibiting compounds OP, carbamates, isocyanates, or detect inhibition NTE. The measured indicated subordinate contribution OP related symptoms. All noted clustered levels. Our data suggest patients after events, which warrants further investigation. be linked known chemical it is not possible infer direct correlation between manifestations -inhibiting this time.