Use of a resin-bound synthetic peptide for identifying a neutralizing antigenic determinant associated with the human immunodeficiency virus envelope.
作者： M. Essex , J.T. Sparrow , D.D. Ho , P. Kanda , R.C. Kennedy
DOI: 10.1016/S0021-9258(18)45641-4
关键词:
摘要: A polyamide-based solid-phase support containing an acid-stable p-(oxymethyl)benzoic acid handle to anchor the COOH-terminal amino was utilized in production of synthetic peptides analogous sequences 503-532 from human immunodeficiency virus (HIV) envelope glycoprotein. The resin-bound peptide used induce antibody response native form glycoprotein 120 both rabbits and mice. This epitope detected on surface HIV-infected cells capable inducing vitro neutralizing HIV response. In addition, sera some individuals exposed react with this bound resin a immunoassay. These data indicate that we have identified antigenic determinant present amino-terminal subunits by utilizing peptides.
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