Autozygosity islands and ROH patterns in Nellore lineages: evidence of selection for functionally important traits.

摘要: The aim of this study was to assess genome-wide autozygosity in a Nellore cattle population and characterize ROH patterns islands that may have occurred due selection within its lineages. It attempts also compare estimates inbreeding calculated from (FROH), genomic relationship matrix (FGRM), pedigree-based coefficient (FPED). average number per animal 55.15 ± 13.01 with an size 3.24 Mb. genome is composed mostly by high shorter segments accounting for 78% all ROH, although the proportion covered them relatively small. indicates moderate levels classical standards, value 7.15% (178.70 Mb). FPED FROH, their correlations (− 0.05 0.26) were low. Estimates correlation between FGRM-FPED zero, while (− 0.01 − 0.07) FGRM-FROH decreased as function length, except FROH > 8Mb (− 0.03). Overall, coefficients not genotyped animals. Autozygosity evident across (n = 62) location did largely differ Enriched terms (p < 0.01) associated defense response bacteria (GO:0042742), immune complex reaction (GO:0045647), pregnancy-associated glycoproteins genes (GO:0030163), organism growth (GO:0040014) described autozygotic islands. Low FPED-FROH indicate most suitable method capturing ancient when pedigree does extend back many generations FROH should be used instead. (p < 0.01) suggest strong response. Non-overlapping lineages greatly explain mechanism underlying functionally important traits cattle.