A Method of Three-Dimensional Visualization of Molecular Processes of Apoptosis

摘要: Apoptosis or programmed cell death plays an important role in many physiological states and diseases. Detection of apoptotic cells, tracing the development apoptosis, drug regulation apoptosis are parts basic research medicine. A large number models have been developed that based on differential equations chemical kinetics, can be expressed a uniform notation using some XML-based languages, such as SBML CellML. We describe CellML simulation environment OpenCell herein. These tools display schematically output results form graphs showing time dependencies component concentrations. However, at present we do not software could represent modelling animations well 3-D models. Using descriptive quantitative discuss approaches to visualize biological processes described by The method was implemented visualization molecular modelled kinetic equations. parameters our scheme determined governing participating components, so is only qualitative but also quantitative. To implement this visualization, C# database forms model complexes developed. mathematical for mitochondria-dependent proposed Bagci et al. [22] case study.