Clonal Compartmentation in the Antibody-Producing Lymph Node

摘要: The antibody synthesizing cell is specifically differentiated toward the production of an immunoglobulin belonging to a single class, exhibiting only one allelic allotypic specificity for each locus and probably possessing activity [1, 2, 3, 4]. antigenic stimulus known induce complex set events, including proliferation immunocompetent cells [5, 6, 7, 8], in lymphopoietic tissue. If specific differentiation preserved through generations, immunopoietic tissue should be constituted by more or less delimited clusters sharing common pattern differentiation.