作者: RAHUL JANDIAL , ALLEN L. HO , MICHAEL L. LEVY , EVAN Y. SNYDER
DOI: 10.1016/B978-012373994-0.50007-5
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摘要: Though currently available clinical treatments and therapies have clearly extended the prognostic outlook for many patients with brain tumors, of these advances are short lived, particularly respect to high-grade gliomas such as glioblastoma multiforme. The missing link a efficacious treatment cancers is more complete understanding basic molecular cellular origin tumors. However, new discoveries stem cell developmental neurobiology now borne cancer hypothesis, drawing off intriguing similarities between neoplastic malignant cells within central nervous system. Investigation this mechanism tumor propagation current frontier biology. Neurosurgery also watching closely promising area focus. “Molecular neurosurgery,” glioma involving biologics, homing neural cells, that target at level individual migratory cell, quickly developing field. This coming progression applied research, coupled modalities, promises comprehensive interventions.