Pediatric human immunodeficiency virus infection and cancer in the highly active antiretroviral treatment (HAART) era.
作者： Elena Chiappini , Elettra Berti , Ketty Gianesin , Maria Raffaella Petrara , Luisa Galli
DOI: 10.1016/J.CANLET.2014.02.002
关键词:
摘要: Highly active antiretroviral therapy (HAART) changed the natural history of pediatric HIV infection. This review focuses on trends HIV-associated cancers in childhood HAART era and analyses potential pathogenetic mechanisms. reduced AIDS-defined-malignancies (ADM), but incidence several non-ADM is increasing. immune activation inflammation, promoting tumorigenesis, can only partially be by HAART. In addition, HIV-infected children may undergo accelerated senescence that favors cancer development. How affects this condition an open question. Lastly, there no evidence prenatal exposure to increases risk childhood, long-term studies are needed.
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