Clinical epidemiology of cardiovascular disease in chronic kidney disease.

摘要: The public health importance of chronic kidney disease (CKD) has only come to be appreciated in the last decade. While glomerular filtration rate (GFR) and urinary albumin creatinine levels are highly predictive mortality, thresholds that may useful for screening much closer 'normal' than generally recognised. When optimising balance between true negative positive mortality prediction, GFR from cystatin C ratios all seem perform similarly. Among older population, rates with creatinine-based lowest those 60 90 ml/min/1.73 m(2), unlike C, where climb monotonically declining GFR. Thus, validity community-dwelling individuals is questionable. Nationally, representative data suggest management modifiable cardiovascular risk factors adults CKD far optimal. This paper explores possibility robust associations function outcomes could caused by an unknown, confounding, shared-risk extrapolates findings renal transplant donor populations support this hypothesis.