Targeted Immunotherapy for Staphylococcal Infections

摘要: Staphylococcal infections represent an enormous burden to the public health system in US and worldwide. While traditionally restricted hospital setting, highly virulent strains have recently emerged that may cause severe, even fatal, disease healthy adults outside healthcare settings. This situation, together with increasing resistance many antibacterials a wide variety of staphylococcal strains, requires vaccine development for diseases be re-evaluated. Finding staphylococci is not trivial, as protective immunity does appear exist at significant degree, which partly due fact our immune constant contact antigens are commensal organisms on human epithelia. Furthermore, most species, Staphylococcus aureus, produces protein A, powerful means evade acquired host defense. two high-profile preparations failed clinical trials within last few years, promising results from novel approaches based combination systematically selected been reported. These combinatory vaccines target microbial surface components recognizing adhesive matrix molecules (MSCRAMMs), family bacterial proteins bind extracellular components. In addition, polysaccharide other nonprotein suitable targets cell surface.