Bilateral Deep-Brain Stimulation of the Globus Pallidus in Primary Generalized Dystonia

摘要: Background Severe forms of dystonia respond poorly to medical treatment. Deep-brain stimulation is a reversible neurosurgical procedure that has been used for the treatment dystonia, but assessment its efficacy limited open studies. Methods We performed prospective, controlled, multicenter study assessing and safety bilateral pallidal in 22 patients with primary generalized dystonia. The severity was evaluated before surgery 3, 6, 12 months postoperatively during neurostimulation, use movement disability subscores Burke–Fahn–Marsden Dystonia Scale (range, 0 120 30, respectively, higher scores indicating greater impairment). Movement were assessed by review videotaped sessions an observer who unaware status. At three months, underwent double-blind evaluation presence absence neurostimulation. also patients' quality...