Testosterone depot injection in male hypogonadism: a critical appraisal.

摘要: Testosterone compounds have been available for almost 70 years, but the pharmaceutical formulations less than ideal. Traditionally, injectable testosterone esters used treatment, they generate supranormal levels shortly after 2- to 3-weekly injection interval and then decline very rapidly, becoming subnormal in days before next injection. The rapid fluctuations plasma are subjectively experienced as disagreeable. undecanoate is a new preparation with considerably better pharmacokinetic profile. After 2 initial injections 6-week interval, following intervals between two always 12-weeks, amounting eventually total of 4 per year. Plasma this nearly range normal men, so its metabolic products estradiol dihydrotestosterone. "roller coaster" effects traditional parenteral not apparent. It reverses hypogonadism on bone muscle parameters sexual functions. Its safety profile excellent due continuous normalcy levels. No polycythemia has observed, no adverse lipid profiles. Prostate well within reference limits. There was impairment uroflow. valuable contribution treatment options androgen deficiency.