Evaluation of the efficacy of loricrin as a diagnostic marker in patients with oral submucous fibrosis

摘要: Introduction: Loricrin is usually observed in abundance keratinizing epithelium response to mechanical stress, which may be associated with development and malignant transformations conditions such as oral submucous fibrosis (OSMF). Therefore, understanding of various molecular mechanisms difference gene expressions between OSMF that normal tissue important. Aim: The aim this study was evaluate the efficacy loricrin a diagnostic marker patients OSMF. Materials Methods: Fifty formalin-fixed paraffin-embedded blocks were obtained from archives department. sample grouped into two groups mucosa (group I; n = 20) II; 30) specimens. tissues immunohistochemically stained antibody further graded on basis staining intensity. Results: immunostaining significantly more cases even stratum granulosum comparison mucosa. Conclusion: can act an early indicator prognostic for detection deleterious changes within