Physiological and pharmacodynamic considerations for route of EPO administration.

摘要: Three intertwined issues--effectiveness, dosage, and route of administration--dominate discussion about recombinant human erythropoietin (rHuEPO). The major biological effect rHuEPO is to regulate the number committed erythroid precursors cause them mature into erythrocytes. constant presence critical sustenance, multiplication, differentiation progenitors that otherwise undergo apoptosis die before they reach maturity. for administration influences plasma concentration-time profiles. erythropoietic response not dependent on peak concentration achieved but duration time levels are maintained above a concentration. High immediately after intravenous doses unnecessary either induce or sustain erythropoiesis. During period relative deficiency invariably follows administration, still rHuEPO-dependent cells in bone marrow. subcutaneous sustains basal interdialytic period, prevents death cells, results more efficient sustained Areas under active investigation include modifications parent hormone novel delivery systems decrease elimination maximize residence circulation.