Maternal vitamin D biomarkers are associated with maternal and fetal bone turnover among pregnant women consuming controlled amounts of vitamin D, calcium, and phosphorus.

摘要: Vitamin D plays a central role in calcium homeostasis; however, its relationship with bone turnover during pregnancy remains unclear due to lack of studies that have rigorously controlled for vitamin and other nutrients known influence metabolism. Similarly, prior investigations the effect on relative nonpregnant state may been confounded by varying intakes these nutrients. Nested within intake study, present investigation sought quantify associations between maternal biomarkers biochemical markers among pregnant (versus nonpregnant) women their fetuses under conditions equivalent adequate related Changes across third trimester were also examined. Healthy (26-29 wk gestation; n=26) (n=21) consumed 511IU D/d, 1.6g calcium/d, 1.9g phosphorus/d 10weeks while participating feeding study featuring two choline doses. Based linear mixed models adjusted influential covariates (e.g., BMI, ethnicity, season), had 50-150% higher (P<0.001) concentrations resorption than women. Among women, increases 25(OH)D period associated (P<0.020) lower osteocalcin deoxypyridinoline at study-end, fetal osteocalcin. In addition, free 25(OH)D, 1,25(OH)2D 24,25(OH)2D tended be negatively (P≤0.063) NTx positively (P≤0.021) CTx. 3-epi-25(OH)D3 was (P≤0.037) study-end. These declines resulting from biomarker coincided albumin-corrected serum concentrations, indicating transfer fetus uncompromised. Notably, none achieved statistical significance Overall, our findings suggest achieving might attenuate third-trimester ensuring sufficient delivery fetus.