Heterotrimeric G-proteins and their role in opioid receptor function
作者： Gabriella Fábián
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摘要: Heterotrimeric G-proteins are signal transducers of heptahelical receptors. They consist α and βγ subunits, both capable interacting with several different effectors. Specific domains in their structures enable them to connect intracellular signaling cascades, such as the adenylyl cyclase, phosphoinositol-bisphosphate or MAP kinase pathways. Their activity is synchronized by components, one being a new protein family termed RGS (regulators G-protein signaling). Members this inhibit function. The localization indicates role plasma membrane- independent processes. Opioid receptors transmit signals mainly via Gi/o proteins. Although heterogeneity opioid ligands (peptides alkaloids) (μ, δ, κ suggested subtypes these classes) reveals complicated picture, unique characteristic high dependence capacity can not be explained without analysis
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