Highly Efficient Enantiospecific Synthesis of Imidazoline-Containing Amino Acids Using Bis(triphenyl)oxodiphosphonium Trifluoromethanesulfonate
作者： Shu-Li You , Jeffery W. Kelly
DOI: 10.1021/OL049439C
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摘要: A highly efficient enantiospecific synthesis of imidazoline-based amino acids is reported from dipeptides composed a C-terminal β-amino-α-amino acid residue using bis(triphenyl) oxodiphosphonium trifluoromethanesulfonate. These imidazolines were easily converted to imidazoles and incorporated into macrolactam analogues bistratamide H without loss stereochemical integrity.
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