An antimicrobial evaluation of plants used for the treatment of respiratory infections in rural Maputaland, KwaZulu-Natal, South Africa.

摘要: Abstract Ethnopharmacological relevance Abundant availability of medicinal plants in the study area offers low cost health care, but scientific validation is needed order to lend credibility traditional use against respiratory infections. Aim This focussed on determining antimicrobial efficacies 30 plant species (independently and various combinations) used for related infections rural Maputaland. Materials methods In vitro minimum inhibitory concentration (MIC) assays were undertaken dichloromethane-methanol (CH2Cl2: MeOH) aqueous extracts, as well hydro-distilled essential oils (for aromatic plants). Selected parts assessed activity a range pathogens i.e. Cryptococcus neoformans (ATCC 14116), Klebsiella pneumoniae 13883), Moraxella catarrhalis 23246), Mycobacterium smegmatis 14468) Staphylococcus aureus 6538). The sum fractional concentrations (∑FIC) was determined traditionally combination. Isobolograms represent MIC values selection interactions where two combined ratios. Results most antimicrobially active extracts that Ozoroa obovata Sclerocarya birrea (0.10 mg/ml) while organic from Parinari capensis subsp. incohata Tetradenia riparia demonstrated noteworthy (0.03 mg/ml) activity. Although both Lippia javanica Eucalyptus grandis by far popular infections, mostly only moderate. Furthermore, 1:1 combination did not display strong interactions, isobolograms demonstrate (against some test organisms) when ratios, predominant additive are evident E. present larger proportions. with O. synergism C. K. pneumoniae, ∑FIC 0.34 0.28 respectively. Various ratios these also predominantly synergistic profile. Conclusion this supports independently treatment ailments Maputaland, results higher frequency do necessarily correlate efficacy.