Antibody levels in adult patients with coeliac disease during gluten-free diet: a rapid initial decrease of clinical importance.

摘要: Coeliac disease (CD) is considered to be the result of a complex interplay intrinsic (genetic) factors and variable extrinsic (environmental) factors. The background CD explains its wide spectrum clinical manifestations. For very long time was more or less childhood, which extremely rare in adults. Nowadays we know that one most common food intolerance disorders. An epidemiological study geographically defined area Sweden (Paper1) showed prevalence 95.5/ 100 000 inhabitants. Among associated diseases an especially high incidence thyroid disease, 10.8% observed. In fifteen-year cohort follow up all CD-patients residing counties Orebro Linkoping (Paper 2) total mortality increased with 38% (SMR 1.38 95% C.I. 0.31-0.83). This mainly explained by 48% death rate ischemic heart significant patients over 65 years 1.58 1.00-2.06). However, there 47 % lower risk malignancies (SIR 0.53 A 22 consecutively biopsy-proven adult 3), were followed respect antibody titres from diagnosis after 1, 3, 6, 12 months on gluten free diet (GFD). All fell sharply within month. Thus excluding serologically patient who has initiated GFD herself not recommend. another IV) diagnosed 8-12 earlier recommended recommended, reliability history, serological biochemical markers predict appearance small intestinal mucosa analysed IV). history strict gave predictive value 88% remission. values tests (AGA, EmA tTG) remission 93% for all. gastro-intestinal symptoms evaluated GSRS questionnaire. Subjects reported significantly GI-symptoms than general population sample (p<0.01). particularly true women scored worse female controls .By contrast men no male controls.