Major depression during interferon-alpha treatment: vulnerability and prevention.

摘要: Major Depressive Disorder (MDD) during interferons (IFN-α) treatment can occur within a few months of therapy, and shares many homologies with other forms MDD, Most patients are resilient to the side effect ofinterferon-induced depression (IFN-MDD), but 15% 40% vulnerable. Several studies have employed antidepressants prevent incidence an IFN-MDD episode, results suggest that prophylactic may be specifically useful in those pre-existing subthreshold depressive symptoms andlor history prior MDD episodes. potential markers vulnerability for been implicated assessments nondepressed before they start IFN-α These include poor sleep quality, premorbid elevations inflammatory cytokines, genetic polymorphisms serotonin system, personality, social support. The interplay these factors strongly predicts who is at risk IFN-MDD, indicates several potentially modifiable targets personalized prevention