Circadian Rhythm Disruption and Alzheimer's Disease: The Dynamics of a Vicious Cycle.

摘要: All mammalian cells exhibit circadian rhythm in cellular metabolism and energetics. Autonomous clocks are modulated by various pathways that essential for robust time keeping. In addition to the canonical transcriptional translational feedback loop, several new of timekeeping - non-transcriptional oscillations, post-translational modifications, epigenetics signaling clock have been identified. The physiology is expansive, its link neurodegeneration multifactorial. Circadian disruption prevelant contamporary society where light-noise, shift-work, transmeridian travel commonplace, also reported from early stages Alzheimer's disease (AD). alignment bright light therapy conjunction with chronobiotics beneficial treating sundowning syndrome other cognitive symptoms advanced AD patients. We performed a comprehensive analysis clinical reports review clock, delineate dysfunction AD, unravel dynamics vicious cycle between two pathologies. delineates role putative targets like proteins PER, CLOCK, BMAL1, ROR, clock-controlled AVP, SIRT1, FOXO, PK2 towards future approaches management AD. Furthermore, aging delineated.